Detailed view for EmuJ_000456500

Basic information

TDR Targets ID: 961196
Echinococcus multilocularis, G1:S specific cyclin D1
Source Database / ID:  GeneDB

pI: 6.0039 | Length (AA): 386 | MW (Da): 43105 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00134   Cyclin, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
27 297 3qhw (B) 172 432 22.00 0.00056 1 1.05167 -0.94
35 272 2w96 (A) 25 264 25.00 0.0031 1 1.07118 -1.39
66 216 1g3n (C) 50 199 31.00 0.00000000004 1 0.851292 -1.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131242)

Species Accession Gene Product
Brugia malayi Bm1_02025   Cyclin, N-terminal domain containing protein
Caenorhabditis elegans CELE_Y38F1A.5   Protein CYD-1
Drosophila melanogaster Dmel_CG9096   Cyclin D
Echinococcus granulosus EgrG_000456500   G1:S specific cyclin D1
Echinococcus multilocularis EmuJ_000456500   G1:S specific cyclin D1
Homo sapiens ENSG00000118971   cyclin D2
Homo sapiens ENSG00000112576   cyclin D3
Loa Loa (eye worm) LOAG_13310   hypothetical protein
Loa Loa (eye worm) LOAG_14566   hypothetical protein
Mus musculus ENSMUSG00000034165   cyclin D3
Mus musculus ENSMUSG00000000184   cyclin D2
Schistosoma japonicum Sjp_0038820   ko:K10151 cyclin D2, putative
Schistosoma mansoni Smp_153660   cyclin d

Essentiality

EmuJ_000456500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y38F1A.5 Caenorhabditis elegans larval arrest wormbase
CELE_Y38F1A.5 Caenorhabditis elegans larval lethal wormbase
CELE_Y38F1A.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cyclin D2 Compounds References
Homo sapiens cyclin D3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1942 1 1
0.0407 0.4829 0.4826
0.155 0.4314 0.4312
0.2183 0.3973 0.3973
0.2442 0.6747 0.6745
0.0564 1 1
0.1986 1 1
0.0888 0.4028 0.4028
0.8405 1 1
0.0202 0.7852 0.7511
0.1622 1 1
0.2972 0.3949 0.3938
0.0299 0.3658 0.4705
0.0178 0.6244 0.6305
0.1386 1 1
0.1609 1 1
0.223 1 1
0.4656 0.3274 0.3274
0.052 0.2719 0.2711
0.0193 1 1
0.0205 0.6153 0.6401
0.1115 1 1
0.0663 0.9642 1
0.019 0.3424 0.3601
0.1236 1 1
0.1171 0.3396 0.3396
0.1622 1 1
0.0155 1 1
0.2183 0.3973 0.3973
0.4657 1 1
0.0879 0.5498 0.5498
0.0198 1 1
0.0191 0.9642 1
0.1075 0.4581 0.4561
0.1038 0.509 1
0.0834 0.6145 0.614
0.0193 0.9222 0.9404
0.0188 0.8892 0.8721
0.0574 1 1
0.0193 0.9298 0.9291
1.1495 1 1
0.1382 0.3671 1
0.5418 1 1
0.0866 0.6177 0.6177
0.0497 0.2955 0.2955
0.4898 1 1
0.4656 0.3274 0.3274
0.3114 1 1
0.0353 0.6179 0.6602
0.0497 0.2824 1
0.2672 1 1
0.8554 1 1
0.0196 0.6009 0.5984
0.4735 1 1
0.022 0.625 0.9918
0.0378 0.2895 0.308
0.0805 0.4946 0.4946
0.2134 1 1
0.129821 1 1
0.4117 1 1
0.5418 1 1
0.9447 1 1
0.0334 1 1
0.2972 0.3949 0.3938
0.6694 0.3084 0.3084
0.1021 1 1
1.09352 1 1
0.107 0.4653 0.465
0.0193 1 1
0.0193 1 1
0.0399 0.3247 0.3695
0.1179 0.4628 0.4628
0.547 0.966 0.966
0.0196 1 1
0.1493 1 1
0.1389 1 1
0.1236 1 1
0.0183 0.2665 0.2785
0.0827 0.6351 0.6351
0.0196 0.9554 1
0.4425 1 1
0.0837 0.501 0.501
0.0787 0.6954 0.7007
0.0171 0.6066 0.7309
0.6927 1 1
0.1281 1 1
0.6329 0.4433 0.4433
0.0884 0.551 0.551
0.0196 1 1
0.543 1 1
0.9053 1 1
0.0196 0.9554 1
0.0193 0.315 0.3007
0.0921 0.5563 0.5563
0.5418 1 1
0.0331 1 1
0.0208 0.7852 0.7511
0.0193 1 1
0.0353 0.2804 0.2985
0.1131 1 1
0.0804 0.496 0.496
0.157 1 1
0.0208 0.7913 0.7511
0.424 1 1
0.0522 0.2652 0.2652
0.1986 1 1
0.0193 0.9298 0.9291
0.1199 0.4075 0.4075
0.0368 0.8688 0.8688
0.0196 0.9554 1
0.298784 0.727013 0.72691
0.019 1 1
0.0193 0.3491 0.3491
0.3013 1 1
0.0327 1 1
0.5463 1 1
0.0406 1 1
0.0196 0.9554 1
0.0193 0.2761 1
0.2947 1 1
0.0389 0.9392 0.9679
0.0196 0.9554 1
0.298784 0.727013 0.72691
0.0193 1 1
0.0667 1 1
0.298784 0.727013 0.72691
0.0403 1 1
0.1119 0.5337 0.5656
0.0193 0.4021 0.5733
0.0196 1 1
0.0183 0.4823 0.5153
0.8327 1 1
0.125 1 1
0.0205 0.3649 0.3649
0.2777 1 1
0.0196 0.9554 1
0.0137 0.3716 1
0.0842 1 1
0.018 1 1
0.4656 0.3274 0.3274
0.0327 1 1
0.3426 1 1
0.0208 0.7852 0.7511
0.0496 0.312 1
0.0158 0.2772 0.2749
0.0193 0.4421 1
0.5263 1 1
0.4656 0.3274 0.3274
0.5418 1 1
0.4656 0.3274 0.3274
0.1013 0.5429 0.5425
0.0201 0.7852 0.7511
0.4656 0.3274 0.3274
0.3191 1 1
0.0375 0.3571 0.512
0.1882 1 1
0.298784 0.727013 0.72691
0.1185 0.3583 0.3583
0.4589 1 1
0.1226 0.289 1
0.8405 1 1
0.4094 1 1
0.7458 1 1
0.0174 0.9626 1
0.549 1 1
0.9053 1 1
0.0198 0.563 0.5859
0.1185 0.3583 0.3583
0.4656 0.3274 0.3274
0.0204 0.2925 0
0.3527 1 1
0.0397 0.7118 0.7208
0.1223 0.4062 1
0.0533 0.4209 1
0.052 0.2719 0.2711
0.1617 1 1
0.2442 0.6747 0.6745
0.1037 0.4744 1
0.2142 1 1
0.0995 0.5729 0.6271
0.5298 1 1
0.0213 0.543 0.63
0.0383 0.2955 0.3146
0.1236 1 1
0.0174 0.9554 1
0.0196 0.9554 1
0.1063 0.5712 1
0.0163 0.2893 0.6649
0.0676 0.4161 0.4143
0.4656 0.3274 0.3274
0.1461 1 1
0.0896 0.5498 0.5498
0.5463 1 1
0.0406 0.2883 0.2881
0.1045 0.3991 0.3986
0.025 0.2618 0.2602
0.0196 0.9554 1
0.1882 1 1
0.0633 0.4424 0.4424
0.9961 1 1
0.1185 0.3583 0.3583
0.1188 0.4407 0.4407
0.2464 1 1
0.0969 1 1
0.038 0.2912 0.3101
0.1294 0.4552 0.4552
0.0196 1 1
0.0188 0.3156 1
0.298784 0.727013 0.72691
0.3671 1 1
0.1129 1 1
0.0196 0.9554 1
0.0196 1 1
0.0181 0.5031 1
0.0855 0.5711 0.5711
0.8405 1 1
0.053 0.3263 0.3263
0.0188 0.3203 1
0.0196 1 1
0.0687 0.4246 1
0.2672 1 1
0.1622 1 1
0.2464 1 1
0.0208 0.7852 0.7511
0.0888 0.4028 0.4028
0.0185 0.6245 0.8119
0.5418 1 1
0.0193 1 1
0.1119 0.5337 0.5656
0.1193 1 1
0.7261 1 1
0.083 0.6464 0.6673
0.0868 0.5529 0.5529
0.0859 1 1
0.0203 0.9138 0.9138
0.4694 1 1
0.0834 0.5083 0.5065
0.0521 0.275 0.275
0.8405 1 1
0.0191 0.5701 0.5851
0.019 1 1
0.0718 1 1
0.657 1 1
0.0937 0.3253 0.3253
0.2972 0.3949 0.3938
0.1309 0.462 0.462
0.0193 1 1
0.0814 0.6455 0.6455
0.0754 0.6213 0.5793
0.0374 0.2804 0.2985
0.1309 0.2894 0.2894
0.0208 0.7411 0.7411
0.0661 0.3753 1
0.0667 1 1
0.4083 1 1
0.0378 0.2895 0.308
0.0756 0.6409 0.6404
0.0656 0.3777 1
0.2286 0.2649 0.2646
0.0158 0.2772 0.2749
0.1622 1 1
0.4302 1 1
0.3856 1 1
0.0754 0.6213 0.5793
0.2309 1 1
0.8405 1 1
0.0515 0.3821 1
0.0842 1 1
0.0804 0.6773 0.692
0.3115 1 1
0.0664 0.9659 1
0.2442 0.6747 0.6745
0.1564 1 1
0.0196 1 1
0.1806 1 1
0.019 1 1
0.0173 1 1
0.0249 0.3451 0.3449
0.0375 0.3571 0.512
0.0203 1 1
0.0208 0.8461 0.8449
0.0325 0.4611 1
0.4023 1 1
0.543 1 1
0.0756 0.6529 0.668
0.1493 1 1
0.0196 1 1
0.0125 0.3126 0.3012
0.052 0.2719 0.2711
0.0193 0.9488 1
0.385239 1 1
0.067 1 1
0.6694 0.2776 0.2776
0.6846 1 1
0.9447 1 1
0.6694 0.2776 0.2776
0.0208 0.7852 0.7511
0.0399 0.3247 0.3695
0.0831 0.6362 0.6362
0.0515 0.4844 1
0.1221 0.5606 1
0.5006 1 1
0.0211 0.563 0.5956
0.0196 1 1
0.0168 0.2714 0.2714
0.0347 0.4802 1
0.041647 1 1
0.0203 0.8892 0.8721
0.8846 1 1
0.0212 0.4871 0.4871
0.1871 1 1
0.025 0.2618 0.2602
0.0369 0.5871 0.5864
0.0633 0.4424 0.4424
0.0509 0.2514 0.2514
0.0331 1 1
0.0851 0.5727 0.5726
0.0367 1 1
0.1067 0.4454 0.4449
0.806 1 1
0.0504 0.2957 1
0.2286 0.2649 0.2646
0.0203 0.7598 0.7579
0.0328 0.2595 1
0.8339 1 1
0.0504 0.2957 1
0.0193 1 1
0.0406 1 1
0.032 0.2755 0.2755
0.543 1 1
0.0163 0.3802 1
0.8103 1 1
0.032 0.2755 0.2755
0.0187 0.5177 0.5177
0.0193 1 1
0.0712 0.8568 0.8568
0.3112 1 1
0.298784 0.727013 0.72691
0.1622 1 1
0.0196 0.964 1
0.9447 1 1
0.1042 0.4263 0.4263
0.4958 1 1
0.0196 0.6009 0.5984
0.0196 0.9554 1
0.0389 0.6519 0.649
0.695 1 1
0.0222 0.6956 0.6956
0.9961 1 1
0.067 1 1
0.2984 1 1
0.0203 0.8935 0.8935
0.0748 0.6483 0.6643
0.0187 1 1
0.0198 1 1
0.3898 1 1
0.3663 0.9582 0.9581
0.2869 1 1
0.0945 1 1
0.1622 1 1
0.6386 1 1
0.0805 0.4946 0.4946
0.0579 0.6015 0.6453
0.0212 0.6323 0.6323
0.0834 0.5083 0.5065
0.0333 0.6913 0.6913
0.1541 1 1
0.0834 0.5083 0.5065
0.0522 0.2652 0.2652
0.0415 1 1
0.0208 0.3493 0.3493
0.1144 0.469 0.4685
0.0505 1 1
0.210679 1 1
0.0443 0.3516 0.3506
0.2017 0.5293 0.5292
0.1209 0.3823 0.3823
0.0321 1 1
0.0193 0.9369 1
0.0193 1 1
0.0888 0.4028 0.4028
0.0995 0.5729 0.6271
0.9447 1 1
0.088 0.564 0.564
0.8905 1 1
0.8554 1 1
0.1171 0.3396 0.3396
0.8405 1 1
0.1013 1 1
0.0708 0.4667 1
0.1554 1 1
0.0196 1 1
0.0349 0.3436 0.3427
0.0333 0.6913 0.6913
0.0196 0.9554 1
0.0833 0.5645 0.5644
0.0193 1 1
0.2442 0.6747 0.6745
0.0837 0.501 0.501
0.0374 0.2804 0.2985
0.0491 1 1
0.0367 0.842 0.8399
0.0196 0.9554 1
0.1223 0.4062 1
0.0508 0.2903 0.2903
0.0188 0.9642 1
0.547 0.966 0.966
0.0196 0.9554 1
0.0196 1 1
0.0203 0.8044 0.7891
0.9053 1 1
0.1036 0.3686 0.3686
0.0208 0.7852 0.7511
0.1143 0.4746 0.5657
0.4109 1 1
0.0299 0.3658 0.4705
0.24 0.6175 1
0.0305 1 1
0.0376 0.6469 1
0.0193 1 1
0.0321 1 1
0.6694 0.2776 0.2776
0.6622 1 1
0.053 0.3263 0.3263
0.0664 1 1
0.1006 1 1
0.0667 1 1
0.0997 1 1
0.0218 0.3959 0.7153
0.3426 1 1
0.1113 0.5148 0.5148
0.9053 1 1
0.0189 0.5933 0.5836
0.0193 1 1
0.4656 0.3274 0.3274
0.08 0.6745 0.6932
0.0495 0.8866 1
0.0173 0.4374 1
0.0174 0.563 0.5956
0.0349 0.3436 0.3427
0.052 1 1
0.1634 1 1
0.0218 0.3959 0.7153
0.3788 0.9773 0.9773
0.4898 1 1
0.0208 0.7852 0.7511
0.0188 0.8892 0.8721
0.726 1 1
0.0209 0.6096 0.6096
0.0208 0.7852 0.7511
0.8846 1 1
0.5729 1 1
0.0193 0.685 1
0.0548 1 1
0.0776 0.3753 0.3753
0.6056 1 1
0.1044 0.4269 0.4269
0.298784 0.727013 0.72691
0.3527 1 1
0.8405 1 1
0.428 1 1
0.1075 0.4581 0.4561
0.0193 1 1
0.0187 0.553 0.553
0.0513 0.2788 0.2782
0.0208 0.7852 0.7511
0.0406 1 1
0.0995 0.5729 0.6271
0.0398 0.4141 0.7511
0.0157 0.9554 1
0.4302 1 1
0.0197 1 1
0.016 1 1
0.0341 0.4722 1
0.2969 1 1
0.0212 1 1
0.6156 1 1
0.0655 0.3836 0.383
0.083 1 1
0.0762 0.6676 0.6777
0.0881 1 1
0.1055 0.4263 0.4263
0.0369 1 1
0.0509 1 1
0.0497 0.2824 1
0.0518 1 1
0.0837 0.6414 0.6414
0.0522 0.2652 0.2652
0.3541 1 1
0.4323 1 1
0.0353 0.6179 0.6602
0.0196 0.9554 1
0.8405 1 1
0.0171 1 1
0.0415 0.2756 0.2727
0.091 0.5454 0.5454
0.2142 1 1
0.4611 1 1
0.8405 1 1
0.0209 0.6096 0.6096
0.0239 0.3081 0.5094
0.0208 0.7852 0.7511
0.0196 0.9554 1
0.0196 0.9655 1
0.5418 1 1
0.0193 1 1
0.034 1 1
0.8312 1 1
0.8405 1 1
0.1171 0.3396 0.3396
0.0508 0.2903 0.2903
0.298784 0.727013 0.72691
0.0172 0.5433 0.5433
0.0415 0.2756 0.2727
0.0172 1 1
0.0323 0.3457 0.9282
0.0501 0.3787 0.378
0.2442 0.6747 0.6745
0.0311 1 1
0.608 1 1
0.0508 0.2903 0.2903
0.0399 0.3247 0.3695
0.0205 0.3312 0.3312
0.0377 0.6594 0.6594
0.0193 1 1
0.0193 1 1
0.4735 1 1
0.2286 0.2649 0.2646
0.2442 0.6747 0.6745
0.1309 0.2894 0.2894
0.3663 0.9582 0.9581
0.052 0.2719 0.2711
0.1161 0.6081 1
0.0823 0.563 0.6904
0.428 1 1
0.4176 0.9824 0.9824
0.0343 0.4778 1
0.5418 1 1
0.0318 0.2662 0.319
0.0406 1 1
0.0181 0.4615 1
0.1882 1 1
0.0326 0.9561 1
0.025 0.2618 0.2602
0.0845 1 1
0.2427 1 1
0.0371 1 1
0.0462 0.3493 0.3706
0.038 0.2912 0.3101
0.896205 1 1
0.0919 0.8297 0.9441
0.0193 0.6109 0.6033
0.4023 1 1
0.0196 0.9554 1
0.0193 1 1
0.0352 0.3366 0.3573
0.3299 1 1
0.0206 0.4081 0.4072
0.0549 1 1
0.0833 0.5645 0.5644
0.5756 1 1
0.183 1 1
0.019 1 1
0.2132 0.5886 0.5886
0.0618 0.7766 0.4522
0.0901 0.5429 1
0.9053 1 1
0.0347 0.6271 1
0.04 0.2895 0.308
0.2256 0.66 0.6598
0.0193 0.9298 0.9291
0.4598 1 1
0.1855 1 1
0.0846 0.6427 0.6427
0.0693 0.9877 1
0.0193 1 1
0.0545 1 1
0.1968 1 1
0.1197 1 1
0.4723 1 1
0.1283 0.9284 0.9283
0.0344 1 1
0.1283 0.9284 0.9283
0.298784 0.727013 0.72691
0.2777 1 1
0.2321 1 1
0.0196 0.964 1
0.1216 0.2793 1
0.1186 0.3859 1
0.7595 1 1
0.1968 1 1
0.0159 0.9458 1
0.6828 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

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Gene identifier EmuJ_000456500 (Echinococcus multilocularis), G1:S specific cyclin D1
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